Check out our new manuscript published in Stem Cell Reports today! In this manuscript, we analyzed transcriptome data from different BMP based pluripotent stem cell differentiation protocols and assessed their ability to differentiate into trophoblast. Our analysis shows that the BMP4 procedure generates TB with similarities to both placental villous TB and TB generated from TB stem cells, and suggests that the transcriptomic signatures between embryonic amnion and different forms of TB have commonalities. Overall, the data provide justification for using TB derived from PSCs as a model for placental development. Thanks to the Roberts Lab for collaborating on this project!
Also check out the paper from the Parast Lab in the same issue of Stem Cell Reports:
Derivation of functional trophoblast stem cells from primed human pluripotent stem cells.
Also check out the paper from the Parast Lab in the same issue of Stem Cell Reports:
Derivation of functional trophoblast stem cells from primed human pluripotent stem cells.