Combined analysis of dissimilar promoter accessibility and gene expression profiles identifies tissue-specific genes and actively repressed networks.

An article from the Tuteja Lab, "Combined analysis of dissimilar promoter accessibility and gene expression profiles identifies tissue-specific genes and actively repressed networks", was published in Epigenetics & Chromatin today! Rebekah Starks, PhD student in Bioinformatics and Computational Biology, is lead author on the paper. In this article, she demonstrates that while tissue-specific genes have high expression, they only have medium-low promoter accessibility according to Atac-seq. This is different from genes associated with house-keeping functions, which have high expression and high accessibility. She also identified a network of neuronal genes that may be actively repressed in the placenta. Congratulations, all!