Our collaborative manuscript was published in PNAS today! We worked with the Michael Soares group to describe the first single-cell RNA-seq atlas of the rat uterine-placental interface. Our team identified cell-specific transcripts for invasive trophoblast, endothelial, smooth muscle, natural killer, and macrophage cells. We also identied similarities in the transcriptomes of rat and human invasive trophoblast cells, leading to the discovery of conserved candidate regulators of the invasive trophoblast cell lineage. This creates opportunities to test hypotheses underlying the pathophysiologic basis of trophoblast cell-guided uterine transformation and new insights into the etiology of diseases of placentation. Congratulations, team!
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