Our collaborative manuscript was published in PNAS today! We worked
with the Michael Soares group to describe the first single-cell RNA-seq
atlas of the rat uterine-placental interface. Our team identified
cell-specific transcripts for invasive trophoblast, endothelial, smooth
muscle, natural killer, and macrophage cells. We also identied similarities
in the transcriptomes of rat and human invasive trophoblast cells,
leading to the discovery of conserved candidate regulators of the
invasive trophoblast cell lineage. This creates opportunities to test
hypotheses underlying the pathophysiologic basis of trophoblast
cell-guided uterine transformation and new insights into the
etiology of diseases of placentation. Congratulations, team!
with the Michael Soares group to describe the first single-cell RNA-seq
atlas of the rat uterine-placental interface. Our team identified
cell-specific transcripts for invasive trophoblast, endothelial, smooth
muscle, natural killer, and macrophage cells. We also identied similarities
in the transcriptomes of rat and human invasive trophoblast cells,
leading to the discovery of conserved candidate regulators of the
invasive trophoblast cell lineage. This creates opportunities to test
hypotheses underlying the pathophysiologic basis of trophoblast
cell-guided uterine transformation and new insights into the
etiology of diseases of placentation. Congratulations, team!