Core conserved transcriptional regulatory networks define the invasive trophoblast cell lineage7/31/2023 ![]() Our collaborative manuscript was published in Development today! We worked with the Michael Soares group to integrate our previously published single-cell RNA-seq data generated in the rat uterine-placental interface with single-nucleus ATAC-seq data generated at the same stage and in the same tissue type. We identified chromatin accessibility profiles in different cell types and identified a conserved gene regulatory network in invasive trophoblast cells. This work will will facilitate future studies investigating regulatory mechanisms in the invasive trophoblast cell lineage.
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