Extracellular vesicles from mouse trophoblast cells: Effects on neural progenitor cells and potential participants in the placenta-brain axis

Check out or new collaborative manuscript where we looked at small RNA content of extracellular vessicles from mouse trophoblast stem cells (TSC) and TSC differentiated into parietal trophoblast giant cells (pTGC). We also looked at how exposure of mouse neural progenitor cells (NPC) to EV from either TSC or pTGC affect their transcriptome profiles. This exciting work is a first step towards understanding how placenta-derived extracellular vessicles may provide direct support for fetal brain development and may be an integral part of the placenta-brain axis. This work was in collaboration with Dr. Rosenfeld and Dr. Roberts from the University of Missouri, Columbia. Also check out this article about Cheryl, her work, and this published work!